| Bioactivity | Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively[1]. |
| Target | SUB1 protease |
| Sequence | Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 |
| Shortening | Ac-{Cpg}-TA-{Ala(CO)}-D-{Cpg}-NH2 |
| Formula | C31H49N7O11 |
| Molar Mass | 695.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Legru A, et al. Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1[J]. European Journal of Medicinal Chemistry, 2024: 116308. |
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
CAS: F: C31H49N7O11 W: 695.76
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibito
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